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目的:建立一种同时测定复方药物中多组分含量的分光光度法。方法:采用K比例H点标准加入法,不经分离直接测定复方磺胺甲噁唑片中磺胺甲噁唑和甲氧苄啶的含量,选择240nm和270nm作为测定波长。结果:磺胺甲噁唑的线性范围0~20ug/m1,平均回收率为100.17%,RSD为0.74%;甲氧苄啶的线性范围0~12ug/ml,平均回收率为99.67%,RSD为1.21%。结论:该方法简便、快速、准确,适合于复方磺胺甲噁唑片的常规分析。
Objective: To establish a spectrophotometric method for simultaneous determination of multi-component in compound drugs. Methods: K-point standard H-point method was used for the determination of sulfamethoxazole and trimethoprim in compound sulfamethoxazole tablets directly without separation. 240nm and 270nm were selected as the determination wavelength. Results: The linear range of sulfamethoxazole was 0 ~ 20 ug / ml with the average recovery of 100.17% and RSD of 0.74%. The linear range of trimethoprim was 0 ~ 12 ug / ml with the average recovery of 99.67% and RSD of 1.21 %. Conclusion: The method is simple, rapid and accurate and suitable for the routine analysis of compound sulfamethoxazole tablets.