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目的 观察黄芪注射液联合硫酸镁注射液治疗妊娠高血压的临床研究.方法 将76例妊娠高血压患者随机分为对照组38例和试验组38例,对照组予以静脉滴注25％的硫酸镁注射液60 mL,每日1次,共7 d;试验组在对照组的基础上予以静脉滴注黄芪注射液60 mL,每日1次,共7 d.比较2组患者的临床疗效、血压、平均动脉压(MAP)和24 h尿蛋白含量变化.结果 治疗后,对照组和试验组的总有效率分别为86.84％(33例/38例)和97.37％(37例/38例),差异有统计学意义(P<0.05).对照组和试验组的收缩压分别为(147.21±20.01),(128.46±18.43)mmHg,舒张压分别为(90.25±15.46),(73.14±14.53)mmHg,MAP分别为(126.76±9.65),(108.15±9.57)mmHg,24 h尿蛋白含量分别为(2.65±0.87),(1.34±0.79)g,差异均有统计学意义(P<0.05).结论 黄芪注射液联合硫酸镁注射液可有效降低妊娠高血压患者血压,改善其妊娠结局,其作用机制可能与上调胎盘组织中PLGF及MMP-9蛋白表达有关.“,”Objective To explore the effects of magnesium sulfate in combination with astragalus membranaceus injection on the birth outcomes and expression of placenta tissue related gene of patients with gestational hypertension. Methods Seventy-six gestational hypertension patients were selected and randomly assigned to control group (n = 38) and treatment group (n = 38). The control group was given intravenous injection of 25％ magnesium sulfate (60 mL) once daily for 7 days,while the treatment group was give intravenous injection of astragalus (60 mL) on the basis of the control group once daily for 7 days. The changes of blood pressure,mean arterial pressure (MAP) and 24 h urine protein content of the two groups were compared. The placenta tissue of the two groups were collected after childbirth. Results After treatment,the total effective rates of the control group and the treatment group were86. 84％ (33/38) and 97. 37％ (37/38) ,respectively; the difference was statistically significant (P < 0. 05). There were significant differences between the control group and the treatment group in systolic blood pressure [(147. 21 ± 20. 01) mmHg vs (128. 46 ± 18. 43) mmHg],diastolic blood pressure [(90. 25 ± 15. 46) mmHg vs (73. 14 ± 14. 53) mmHg],MAP [(126. 76 ± 9. 65) mmHg vs (108. 15 ± 9. 57) mmHg] and the 24 h urine protein content [(2. 65 ±0. 87) g vs (1. 34 ±0. 79) g](P < 0. 05). Conclusion Magnesium sulfate combined with astragalus membranaceus injection can reduce the blood pressure of gestational hypertension patients,improve the pregnancy outcome; the action mechanism maybe related to the up-regulation of PLGF and MMP-9 protein expression of placenta tissue.