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目的观察和评价复方乌骨藤汤联合化疗治疗晚期非小细胞肺癌的临床疗效和不良反应。方法选择非小细胞肺癌(热毒壅肺,痰瘀互结,气虚血瘀证)患者108例,随机分为复方乌骨藤汤联合化疗组(治疗组)38例、单纯化疗组(对照1组)36例及单纯复方乌骨藤汤组(对照2组)34例,两组化疗均采用NP方案,完成2个周期后进行疗效评价。结果治疗组有效率为73.7%,对照1组有效率为41.7%,对照2组有效率为47.1%,治疗组分别同两对照组比较,差异均有统计学意义(P<0.05);两对照组间比较差异无统计学意义(P>0.05);治疗组在中医分型疗效分析、体重变化及生活质量等方面疗效均明显优于对照1组(P均<0.05),治疗组与对照2组比较差异无统计学意义(P均>0.05);治疗组同对照2组NK细胞活性及CD4/CD8比值治疗后明显高于治疗前(P<0.01);治疗组及对照2组不良反应发生率明显低于对照1组(P均<0.05)。结论复方乌骨藤汤联合化疗治疗晚期非小细胞肺癌(热毒壅肺,瘀瘀互结,气虚血瘀证)有较好疗效,能有效改善临床症状,提高免疫功能,明显提高复方乌骨藤汤的治疗效果,并对化疗药物有明显的增效减毒作用。
Objective To observe and evaluate the clinical efficacy and side effects of compound WuGuTeng decoction combined with chemotherapy in the treatment of advanced non-small cell lung cancer. Methods One hundred and eighty patients with non-small cell lung cancer (HTD, phlegm and blood stasis, Qi-deficiency and blood-stasis syndrome) were randomly divided into three groups: 38 patients in combination with Wuweiteng Decoction (combined treatment group) and 38 patients in chemotherapy alone group Group), 36 cases and pure compound WuGuTeng decoction group (control group 2) 34 cases. Both groups were treated with NP regimen. The therapeutic effect was evaluated after completing 2 cycles. Results The effective rate was 73.7% in the treatment group, 41.7% in the control group 1, 47.1% in the control group 2, and there were significant differences between the two groups (P <0.05) There was no significant difference between the two groups (P> 0.05). The curative effect of the treatment group was better than that of the control group (P <0.05) in the curative effect of TCM classification, body weight change and quality of life. There was no significant difference between the two groups (P> 0.05). The NK cell activity and CD4 / CD8 ratio in treatment group and control group 2 were significantly higher than those before treatment (P <0.01); adverse reactions in treatment group and control group 2 The rate was significantly lower than the control group 1 (all P <0.05). Conclusion Compound Wu Guotang Decoction combined with chemotherapy in the treatment of advanced non-small cell lung cancer (heat toxic lungs, stasis stasis, Qi deficiency and blood stasis) have a good effect, can effectively improve clinical symptoms, improve immune function, significantly improve the compound black bone Teng Tang treatment effect, and chemotherapy drugs have obvious synergies attenuated.