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目的:观察加味鳖甲煎丸对白蛋白所致大鼠免疫性肝纤维化的防治作用。方法:用人血清白蛋白给大鼠皮下注射免疫4次,在大鼠明显产生抗体后分组给药,再由尾静脉注射人血清白蛋白9次,可得到肝纤维化实验动物模型,实验结束后处死大鼠,收集血清,测定血清AST、ALT、TP、ALB、TBIL、A/C和CIV、LN、HA的含量。结果:同模型组相比,加味鳖甲煎丸能显著降低肝纤维化大鼠血清AST、ALT、TBIL、CIV、LN、HA含量;能显著增加TP、ALB含量和A/G比值,能显著改善大鼠肝纤维化程度。结论:加味鳖甲煎丸对白蛋白所致大鼠免疫性肝纤维化有较好的防治作用。
Objective: To observe the preventive and therapeutic effects of Jiawei Biejiajian Pills on albumin induced immune fibrosis in rats. METHODS: Rats were immunized subcutaneously with human serum albumin four times. After the rats had apparently produced antibodies, they were administered in groups. After injection of human serum albumin 9 times through the tail vein, an experimental animal model of hepatic fibrosis was obtained. After the end of the experiment, Rats were sacrificed, serum was collected and serum AST, ALT, TP, ALB, TBIL, A/C and CIV, LN, and HA levels were determined. Results: Compared with the model group, Jiawei Biejiajian Pill can significantly reduce the serum AST, ALT, TBIL, CIV, LN, HA content in rats with hepatic fibrosis; it can significantly increase the TP, ALB content and A/G ratio, and can significantly Improve liver fibrosis in rats. Conclusion: Jiawei Biejiajian Pill has better preventive and therapeutic effect on albumin induced immune fibrosis in rats.