论文部分内容阅读
目的 观察轻度空腹高血糖人群饮食和/或运动的干预效果、及胰岛素抵抗对干预效果的影响。方法 选取初诊发现空腹血糖在6.1～7.8mmol/L之间的轻度空腹高血糖者129人,按不同干预方法随机分为单纯饮食组、饮食+运动组和对照组3组,在初访和随访1年后分别测量空腹血糖、空腹胰岛素,比较不同干预方法降低空腹血糖的作用,以及胰岛素抵抗的程度对干预效果的影响。结果 干预1年后,饮食+运动组平均空腹血糖低于单纯饮食组[(5.91±1.0)mmol/L,(6.9±1.5)mmot/L,P=0.000],平均胰岛素敏感性指数显著提高(-3.7±0.5,-4.0±0.6,P=0.011);单纯饮食组与对照组相比平均空腹血糖水平差异无显著性[(6.9±1.5)mmol/L,(7.1±1.0)mmol/L,P=0.454],但平均胰岛素敏感性指数显著升高(-4.0±0.6,-4.4±0.7,P=0.003)。以胰岛素敏感性指数值-4.2146为截点做分层分析,与干预前比较,胰岛素抵抗较轻干预组平均空腹血糖明显下降[(6.7±0.6)mmol/L,(6.2±1.0)mmol/L,P=0.001],胰岛素抵抗较重干预组血糖维持原有水平[(6.7±0.5)mmol/L,(6.6±1.6)mmol/L,P=0.505)。干预1年后的血糖变化与胰岛素敏感性改变、运动量的增加和每日摄入热量的改变存在线性相关(P<0.05)。结论 饮食、运动干预能改善高血糖人群胰岛素敏感性,使血糖、血压水平明显下?
Objective To observe the intervention effect of diet and / or exercise on mild fasting hyperglycemia and the effect of insulin resistance on the intervention. Methods 129 newly diagnosed mild fasting hyperglycemia patients with fasting blood glucose between 6.1 ~ 7.8mmol / L were randomly divided into three groups according to different intervention methods: diet group, diet + exercise group and control group. One year after follow-up, fasting blood glucose and fasting insulin were measured respectively. The effects of different fasting blood glucose lowering methods and the extent of insulin resistance on the intervention were compared. Results After 1 year of intervention, the average fasting blood glucose in the diet + exercise group was significantly lower than that in the simple diet group [(5.91 ± 1.0) mmol / L, (6.9 ± 1.5) mmot / L, P = 0.000] -3.7 ± 0.5, -4.0 ± 0.6, P = 0.011). Compared with the control group, the average fasting blood glucose level in the diet group was not significantly different [(6.9 ± 1.5) mmol / L, (7.1 ± 1.0) mmol / P = 0.454], but the mean insulin sensitivity index was significantly higher (-4.0 ± 0.6, -4.4 ± 0.7, P = 0.003). The mean value of fasting blood glucose (P <0.05) was significantly lower than that before the intervention ([6.7 ± 0.6] mmol / L, (6.2 ± 1.0) mmol / L , P = 0.001]. The patients with severe insulin resistance maintained the original blood glucose level [(6.7 ± 0.5) mmol / L, (6.6 ± 1.6) mmol / L, P = 0.505). One year after intervention, there was a linear correlation between changes of blood glucose and changes of insulin sensitivity, exercise volume and daily intake of calories (P <0.05). Conclusion Diet and exercise intervention can improve the insulin sensitivity in hyperglycemic subjects and make blood glucose and blood pressure levels significantly lower.