许多研究表明:麻风病的临床和组织学“光谱”系由宿主对麻风杆菌的免疫反应所决定的。瘤型麻风似具有特异性的细胞免疫缺陷,而结核样型病人的此种缺陷则不太明显。瘤型麻风的这种特异性的细胞免疫抑制,具有宿主依赖性的特征。它可能由遗传所决定。而决定对某些抗原的免疫反应性的基因则与主要的组织相容性基因密切相连。鉴于人体的组织相容系统,即HLA,与许多种疾病有密切关 Many studies show that the clinical and histological “spectrum” of leprosy is determined by the host’s immune response to M. leprae. Tumor-like leprosy has a specific cellular immune deficiency, and tuberculosis-like patients such defects are less obvious. This specific immunosuppression of leprous leprosy has host-dependent characteristics. It may be genetically determined. The genes that determine the immunoreactivity to certain antigens are closely linked to major histocompatibility genes. Given the body’s histocompatibility system, HLA, is closely related to many diseases