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近10多年来证明至少在部分纯红细胞再障(PRCA)患者T细胞具有病原学作用,但T细胞增多属于克隆源性还是继发的现象尚未阐明。作者报道3例PRCA患者中2例证实存在克隆性T细胞群。 3例PRCA患者中2例为女性,1例男性;年龄58～68岁。1例合并慢性淋巴细胞白血病,2例为特发性。骨髓检查均符合PRCA。无自身免疫病的临床和免疫学依据。对环胞素或皮质类固醇激素治疗敏
In the past 10 years, it has been demonstrated that at least T cells in some patients with pure red cell aplasia (PRCA) have etiologic effects. However, the phenomenon of whether clonogenicity or secondary T cell proliferation is secondary or not has not yet been elucidated. The authors report that 2 of 3 PRCA patients confirmed the presence of clonal T cell populations. Two of the three PRCA patients were female and one male, aged 58-68 years. 1 case complicated with chronic lymphocytic leukemia and 2 cases idiopathic. Bone marrow examination are in line with PRCA. No autoimmune disease clinical and immunological basis. Cyclosporine or corticosteroid therapy sensitive