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应用气相色谱法测定我国137名正常志愿者一次口服美芬妥英(100mg)和异喹胍(10mg)尿样中S/R美芬妥英比值和异喹胍/4-羟异喹胍比值。研究结果表明,137名志愿者中有20名为S-美芬妥英羟化代谢的弱代谢者(PMs),其缺陷频发率为14.6%,说明我国人群的S-美芬妥英羟化代谢缺陷频发率与日本人相近,但明显高于白种人。研究结果尚发现,137名志愿者有2例为异喹胍羟化代谢弱代谢者,其缺陷频发率为1.46%,并与S-美芬妥英羟化代谢表型不相关。这说明两药虽在体内均进行4-羟化代谢,但却被不同的细胞色素P_(450)羟化酶所催化和受不同酶基因所调控。
Gas chromatography was used to determine the ratio of S / R mephenytoin and isoquercitrin / 4-hydroxyquudine in oral once-a-day mephenytoin (100mg) and isoquinidine (10mg) urine samples from 137 normal volunteers in China. . The results showed that 20 out of 137 volunteers were S-mephenytoin metabolizers of weak metabolizers (PMs), the frequency of which was 14.6%, indicating that S-mephenytoin in our population Frequency of metabolic defects and Japanese similar, but significantly higher than Caucasians. The results also found that 137 volunteers in 2 cases of quercetin hydroxylation metabolism weak metabolizers, the frequency of defects was 1.46%, and S-mephenytoin hydroxylated metabolic phenotype is not related. This shows that although the two drugs in the body are 4-hydroxy metabolism, but by different cytochrome P (450) hydroxylase catalyzed by different enzyme gene regulation.