在过去的 10年 ,喹诺酮类药物领域发生了深刻的变化 ,新的化合物、新的观念不断出现 ,对一些分子的毒性和耐药性的危险性有了新的认识。对喹诺酮类药物分子的改造可以明显改变其抗菌活性、药物动力学和代谢性质。例如 ,在 C6 -位的 1个 F可以提供抗葡萄球菌活性 ;C8-位的第 2个 Over the past 10 years, profound changes have taken place in quinolones, new compounds and new concepts are constantly emerging, and some new insights into the molecular toxicity and risk of drug resistance have emerged. Modification of quinolone molecules can significantly alter their antibacterial activity, pharmacokinetics and metabolic properties. For example, one F at the C6-position may provide anti-staphylococcal activity; the second at the C8-position