目前血浆蛋白电泳已成为常规检查项目,对多种疾病患者作检查时可发现一个或更多的副蛋白带。这一发现的意义常可能难以评价。晚期骨髓瘤病人根据骨和血液学的异常,结合本周氏蛋白尿和骨髓的异常表现,诊断常是明确的。淋巴浆细胞样淋巴瘤病人(包括Waldenstr m’s巨球蛋白血症)经淋巴结活检和骨髓检查,诊断通常也不会非常困难。在一般人中副蛋白血症较为少见,但其发病率随年龄而增加。Axelsson对近7,000人的研究表明,60岁以下有副蛋白血症者占1%,70岁以上者占3%。其中仅2例有恶性疾病,1例患骨髓瘤,另1例为慢性淋巴细胞性白血病。其余的人经5年半随访均未发生恶性骨髓瘤或淋巴瘤。当副蛋白的量低于10g/L,其它免疫球蛋白的浓度正常,无本周氏蛋白尿和以后几年内副蛋白的浓度不增高,则可确诊为良性副蛋白血症。Hobbs描述符 At present, plasma protein electrophoresis has become a routine test item, and one or more accessory protein bands can be found when examining a variety of diseases. The significance of this finding can often be difficult to evaluate. Advanced myeloma patients based on bone and hematological abnormalities, combined with this week’s proteinuria and bone marrow abnormalities, the diagnosis is often clear. Lymphoid plasmacytoid lymphoma patients (including Waldenstr m’s macroglobulinemia) by lymph node biopsy and bone marrow examination, the diagnosis is usually not very difficult. Paraxemia is less common in most people, but its incidence increases with age. Axelsson’s study of nearly 7,000 people shows that parakeratins are less than 60% of patients under the age of 1%, 3% over the age of 70%. Of these, only 2 had malignant disease, 1 had myeloma, and the other had chronic lymphocytic leukemia. The remaining 5 years of follow-up were no malignant myeloma or lymphoma. When the amount of paraprotein is less than 10g / L, the concentration of other immunoglobulins normal, without this Zhou proteinuria and the concentration of paraprotein in the next few years is not increased, you can be diagnosed as benign pseudoproteinoidemia. Hobbs descriptor