论文部分内容阅读
目的:探讨缓解期双相情感障碍I型、II型患者及其近亲属认知功能的临床特征。方法对50例缓解期双相障碍I型患者(BP‐1组)、50例缓解期双相障碍II型患者(BP‐2组)、50名健康近亲属(亲属组)及50名正常人群(对照组)采用持续操作测验和威斯康星卡片分类测验进行测评分析。结果 BP‐1组、BP‐2组及亲属组持续操作测验的正确数评分显著低于对照组(P<0.05),且BP‐1组显著低于BP‐2组和亲属组(P<0.05)。BP‐1组、BP‐2组和亲属组威斯康星卡片分类测验的错误应答数、非持续性错误数显著高于对照组(P<0.05或0.01);BP‐1组、亲属组显著高于BP‐2组(P<0.01);BP‐1组和亲属组总应答数、完成分类数、正确率、完成第一个分类数所需要应答数、不能维持完整分类数与对照组及BP‐2组比较差异有显著性(P<0.05或0.01)。结论缓解期双相情感障碍I型、II型患者及其近亲属存在多维度认知功能损害,I型患者任务管理能力损害较明显,II型患者注意力损害明显。“,”Objective To explore the clinical features of cognitive function in paracmasia bipolar I and II patients and their near relatives .Methods Assessments were carried out with the Continuous Performance Test (CPT ) and Wisconsin Card Sorting Test (WCST ) in 50 paracmasia bipolar I patients (BP‐1 group) , 50 II ones (BP‐2 group) ,50 healthy near relatives (relative group) and 50 health adults (control group) . Results Scores on accurate number of the CPT were significantly lower in BP‐1 ,BP‐2 and relative than control group (P<0 .05) ,so were those in BP‐1 than BP‐2 and relative group (P<0 .05) .The number of response errors and that of non‐perseverative errors of the WCST were significantly higher BP‐1 ,BP‐2 and relative than control group (P<0 .05 or 0 .01) ,so were those in BP‐1 and relative than BP‐2 group (P<0 .01);the number of total responses ,categories completed ,correct rate ,responses needed to complete first category ,incomplete category were significantly different in BP‐1 and relative from those in control and BP‐2 group (P<0 .05 or 0 .01) .Conclusion Paracmasia bipolar I and II patients and their near rela‐tives have multi‐dimension cognitive dysfunction ,task management ability impairment of bipolar I ones and attention impairment of bipolar II ones is more obvious .