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依那普利(苯酯丙脯酸,enalapril,MK_(421))是近年来国外已用于临床的又一个血管紧张素转换酶抑制剂,该药口服后吸收率达60-70％以上,吸收后经肝脏水解脱酯成有活性的MK_(422),半减期达35h,作用机理可能与血管紧张素的降低和缓激肽的升高有关。单独使用该药治疗高血压有效率可达50％,加用噻嗪类利尿药有数率可提高到80-85％。它能降低肺毛细血管楔压,提高心脏指数,改善病人心功能,故也可治疗充血性心力衰竭。副作用有皮疹、白细胞减少等,偶可出现低血压。
Enalapril (phenylpropionate, enalapril, MK_ (421)) is another angiotensin converting enzyme inhibitor which has been used clinically in recent years in the world. Its absorption rate after oral administration is over 60-70% Absorption after dehydroxylation of dehydroxylases to active MK_ (422), half-down for 35h, the mechanism may be related to the reduction of angiotensin and elevated bradykinin. The drug alone used to treat hypertension can reach 50% efficiency, plus the number of thiazide diuretics can increase the number of 80-85%. It can reduce pulmonary capillary wedge pressure, improve cardiac index, improve patient’s heart function, it can also treat congestive heart failure. Side effects of rash, leukopenia, even with hypotension.