神经元核内包涵体 (neuronalintran ulearinclusions,NIIs)是遗传性神经变性疾病的一种重要的病理表现 ,尤其在三核苷酸重复疾病 (tripletrepeatdis ease)中更被视为特征性的病理表现 ,尽管分子遗传学研究已证实基因突变导致的三核苷酸重复的异常扩增引起了相应的临床疾病 ,但 Neuronal intranuclear inclusions (NIIs) are an important pathological manifestation of hereditary neurodegenerative diseases and are more likely to be characterized as pathological manifestations, especially in triple-torsion disorders Molecular genetic studies have confirmed that the abnormal amplification of trinucleotide repeats caused by mutations leads to the corresponding clinical disease, but