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[目的]探讨腔内化疗配合全身化疗治疗晚期胃肠道恶性肿瘤的临床疗效。[方法]将术后腹腔转移或失去手术时机的晚期胃肠道癌随机分为治疗组和对照组。治疗组亚叶酸钙(CF)、呋喃氟尿嘧啶(FT 207)、顺铂(PDD)联用 ,行腹腔联合静脉化疗 ,对照组行CF、FT 207、PDD联用单纯静脉化疗 ,两组化疗药物总剂量相同。[结果]治疗组有效率为66.67 % ,1年生存率为60 % ;对照组有效率为40.54% ,1年生存率为35 % ,统计学差异明显(P<0.05) ,而治疗组不良反应明显轻于对照组(P<0.01)。[结论]LFP方案腹腔联合静脉化疗是治疗晚期胃肠道恶性肿瘤的有效方法 ,较单纯静脉化疗毒副作用明显减轻 ,有效率及1年生存率有所提高。
[Objective] To investigate the clinical efficacy of intracavitary chemotherapy combined with systemic chemotherapy in the treatment of advanced gastrointestinal cancer. [Methods] Patients with advanced gastrointestinal cancer after abdominal cavity metastasis or loss of surgical timing were randomly divided into treatment group and control group. In the treatment group, calcium folinate (CF), furan fluorouracil (FT 207), and cisplatin (PDD) were used in combination to perform intraperitoneal venous chemotherapy. In the control group, CF, FT 207, and PDD were combined with intravenous chemotherapy alone. The same dose. [Results] The effective rate in the treatment group was 66.67 % and the 1-year survival rate was 60 %. The effective rate in the control group was 40.54% and the 1-year survival rate was 35 %. The statistical difference was significant (P < 0.05). The adverse reactions in the treatment group It was significantly lighter than the control group (P<0.01). [Conclusion] LFP combined with intraperitoneal venous chemotherapy is an effective method for the treatment of advanced gastrointestinal malignancy. Compared with simple intravenous chemotherapy, the side effects are significantly reduced, and the effective rate and 1-year survival rate are improved.