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目的 建立中性红清除试验测定胃粘膜血流量的方法 ,并观察静脉给予川芎嗪对家兔及胃窦炎和消化性溃疡 (PU)患者胃粘膜血流量的影响。方法 采用中性红清除试验法 ,观察家兔及病人静脉注射川芎嗪前后胃粘膜血流量的变化。病人随机分为川芎嗪组及对照组。结果 家兔静脉注射注射川芎嗪后胃粘膜血流量明显增高。 40例胃窦炎及PU患者中川芎嗪组胃液量、胃液中性红及胃粘膜血流量均于用药后显著升高 ,并于 6 0分钟达到高峰。两组之间胃粘膜血流量的增加有极显著性差异 (P <0 0 1 )。胃液中性红与胃液量均分别与胃粘膜血流量之间存在正相关关系 (r分别 =0 6 5 6及 0 6 76 ,P均 <0 0 0 1 )。结论 本文研究表明 :川芎嗪可增加胃粘膜血流量。其作用可能与扩张胃粘膜血管有关。
Objective To establish a method for determination of gastric mucosal blood flow by neutral red clearance test, and observe the effect of intravenous administration of tetramethylpyrazine on gastric mucosal blood flow in rabbits and antral gastritis and peptic ulcer (PU) patients. Methods Neutral red clearance test was used to observe the change of gastric mucosal blood flow before and after intravenous administration of tetramethylpyrazine in rabbits and patients. Patients were randomly assigned to the tetramethylpyrazine group and the control group. Results The blood flow of gastric mucosa was significantly increased after intravenous injection of tetramethylpyrazine in rabbits. In 40 cases of antral gastritis and PU patients, the amount of gastric juice, neutral red in gastric juice and gastric mucosal blood flow were significantly increased after administration and the peak value was reached at 60 minutes. There was a significant difference in the increase of gastric mucosal blood flow between the two groups (P < 0 01). There was a positive correlation between the neutral redness of gastric juice and the amount of gastric juice and gastric mucosal blood flow (r = 0 6 5 6 and 0 6 76, P <0 0 0 1). Conclusion This study shows that: Ligustrazine can increase gastric mucosal blood flow. Its role may be related to the expansion of gastric mucosal blood vessels.