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目的探讨金属硫蛋白(Metallothionein,简称MT)与男性不育精浆铅镉、精子参数的关系。方法采用钨舟原子吸收光谱法检测患者口服金属硫蛋白前、后精浆铅Pb镉Cd的浓度;采用(computer aided semen anlysis,CASA)方法检测精子质量,分析各组数据间有无统计学意义。结果服用MT1-2个疗程前后进行统计学配对t检验:精子活率检测,密度、活率达到正常参考值的分别为46.8% P<0.05统计学上有显著差异、34.78% P<0.001统计学上有极显著差异。精子密度、精子活率的改善率分别为58.69% P<0.05统计学上有显著差异、56.52%<0.05统计学上有显著差异。结论口服MT后精子参数有不同程度的改善,对方怀孕11人占19.64%。
Objective To investigate the relationship between Metallothionein (MT) and lead, cadmium and sperm parameters in male sterile semen. Methods Tungsten cadmium atomic absorption spectrometry was used to detect the concentrations of lead, cadmium and cadmium in seminal plasma of patients before and after oral administration of metallothionein. The quality of sperm was detected by computer aided semen anlysis (CASA) method. The data of each group were analyzed statistically . Results Before and after treatment with MT1-2, statistical paired t-test showed that there was a statistically significant difference in sperm motility, density and viability between the two groups (46.8%, P <0.05, 34.78%, P <0.001) There are very significant differences. Sperm density, sperm motility rates were 58.69% P <0.05 statistically significant differences, 56.52% <0.05 statistically significant differences. Conclusion Oral MT after sperm parameters have improved to varying degrees, the other 11 were pregnant 19.64%.