目的:以麻黄汤为例,采用路径分析模型对组方原理进行分析,检验模型图与麻黄汤经典组方理论的吻合度,探索路径分析模型应用于中药复方研究的合理性。方法:采用正交设计进行方中药味的剂量组合,以发汗和止咳二指标反映方剂整体疗效。将组方药量和药效数据进行路径分析,描绘出多个药味与二药效指标间的总体路径图,用图中各药味的正向系数表示其方剂地位,以药味间网络系数表征七情合和。结果:利用路径图解析方法,可以得出复方中各药味对整体药效作用的方向量化指标,并标出药味的组方地位,反映药味间的七情和合。结论:从麻黄汤发汗和止咳两主要药效角度,各路径系数可反映药味在复方中的组方地位,这和“麻黄为君、臣以桂枝、佐以杏仁和使以甘草”的组方原则相吻合。路径分析方法对中药复方各药味组方地位而言具有一定的可行性。 Objective: Taking Mahuang Decoction as an example, the path analysis model was used to analyze the principle of group prescription. The coincidence degree between the model diagram and the classical prescription theory of Mahuang decoction was tested and the rationality of applying the path analysis model to the study of traditional Chinese medicine compound was explored. Methods: Orthogonal design was used to study the dose combination of Chinese herbs. The two indexes of sweating and cough were used to reflect the overall efficacy of the prescription. The pathological analysis of the group prescription dose and efficacy data, depicting the overall route map between the number of drug effects and two pharmacodynamic indicators, with each positive and negative coefficient of the figure that the prescription position, to characterize the seven emotions network of drugs Together. Results: With the method of path map analysis, we can draw the direction quantification index of all the medicinal herbs in the prescription on the whole medicinal effect and mark the group prescription position of the medicinal herbs, which reflects the seven emotions and the combination between the medicinal herbs and herbs. Conclusions: From the perspectives of the main efficacy of Mahuang decoction in relieving sweat and relieving cough, the path coefficients can reflect the prescription status of the medicinal herbs in the compound prescription. This is consistent with the fact that "ephedra is the king, The principle of the group is consistent. The method of path analysis has certain feasibility for the prescription status of each compound prescription of traditional Chinese medicine.