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目的探讨晚孕期和临产后母血中胎儿DNA含量的变化及其临床意义。方法运用实时荧光定量PCR技术分别检测孕28~42周以及临产时孕妇血浆中胎儿DNA的含量并进行比较。结果孕28~31周、孕32~35周、孕36~42周和临产时的母血浆中胎儿DNA的平均含量比较差异有显著性(F=308.19,q=11.59~40.33,P<0.01)。结论随着孕期的进展,母血中胎儿DNA含量的升高可能是分娩的诱因之一。
Objective To investigate the changes of fetal DNA content in maternal blood during late pregnancy and after labor and its clinical significance. Methods The contents of fetal DNA in pregnant women at 28-42 weeks of pregnancy and at the time of labor were detected by real-time fluorescence quantitative PCR and compared. Results The average content of fetal DNA in maternal plasma at 28-31 weeks pregnant, 32-35 weeks pregnant, 36-42 weeks pregnant and at labor was significantly different (F = 308.19, q = 11.59-40.33, P <0.01) . Conclusion With the progress of pregnancy, the increase of fetal DNA in maternal blood may be one of the causes of labor.