论文部分内容阅读
目的探讨宫颈粒细胞肉瘤(GS)的病理特点、诊断与鉴别诊断及治疗与预后。方法观察1例原发性宫颈粒细胞肉瘤组织学形态及免疫组化,并复习相关文献,综合分析其临床病理特征及治疗与预后。结果本例首发症状为接触性出血、宫颈肥大、质硬。B超示宫颈处有一大小为2.5 cm×1.7 cm低回声占位肿块。光镜示瘤细胞呈弥漫性分布,由淋巴样细胞构成。瘤细胞小至中等大小,胞质少,核呈圆形或椭圆形,核分裂象易见。免疫组化:CD45、MPO、CD43、溶菌酶和CD68均(+),Ki-67阳性指数70%。骨髓及外周血无急性髓细胞白血病表现。结论宫颈粒细胞肉瘤十分罕见,初诊时易误诊为恶性淋巴瘤及小细胞性恶性肿瘤。免疫组化有助于诊断及鉴别诊断。
Objective To investigate the pathological features, diagnosis, differential diagnosis, treatment and prognosis of cervical granulosarcoma (GS). Methods One case of primary cervical granulosarcoma was observed histologically and immunohistochemically. Relevant literatures were reviewed, and the clinicopathological features, treatment and prognosis were analyzed. Results The first symptom of this case is contact bleeding, cervical hypertrophy, hard. B ultrasound showed a small cervix 2.5 cm × 1.7 cm hypoechoic masses. Light microscopy tumor cells were diffuse distribution, composed of lymphoid cells. Tumor cells small to medium size, less cytoplasm, the nucleus was round or oval, mitotic easy to see. Immunohistochemistry: CD45, MPO, CD43, lysozyme and CD68 (+), Ki-67 positive index of 70%. Bone marrow and peripheral blood without acute myeloid leukemia performance. Conclusion Cervical granulosarcoma is very rare, when first diagnosed easily misdiagnosed as malignant lymphoma and small cell malignancy. Immunohistochemistry contributes to the diagnosis and differential diagnosis.