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目的考察不同磷脂对鸦胆子油乳注射液溶血结果的影响。方法通过选择豆磷脂和卵磷脂作乳化剂分别与鸦胆子油制成脂肪乳剂,经过加速试验,经体外溶血试验检查,选择更有利于制备鸦胆子油乳注射液的乳化剂。结果精制蛋黄卵磷脂作乳化剂可以延长鸦胆子油乳注射液的溶血出现时间,加入维生素E后溶血出现时间会进一步延长。结论可以用精制蛋黄卵磷脂代替豆磷脂作乳化剂制备鸦胆子油乳注射液。
Objective To investigate the effect of different phospholipids on hemolysis of Brucea javanica oil emulsion injection. Methods The soybean milk phospholipid and lecithin emulsifier were chosen to make the fat emulsion with Brucea javanica oil respectively. After accelerated test and in vitro hemolysis test, the emulsifier was chosen to be more conducive to the preparation of Brucea javanica oil emulsion injection. Results Refined egg yolk lecithin as emulsifier can extend the time of hemolysis of Brucea javanica oil emulsion injection. After adding vitamin E, hemolysis appears longer. Conclusion Brucea javanica oil injection can be prepared by using refined egg yolk lecithin instead of bean phospholipid as emulsifier.