论文部分内容阅读
目的分析阶梯式卡维地洛对慢性心力衰竭(慢性心衰)患者心室重塑及心功能的影响。方法随机将2013年3月—2015年3月收治的76例慢性心衰患者分为两组,各38例,对照组采取常规抗心衰治疗,观察组在对照组基础上加以卡维地洛阶梯式给药,比较两组治疗前后心功能指标、治疗后心功能分级及不良反应情况。结果观察组治疗后左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)分别为(48.8±8.5)%、(56.2±10.4)mm、(42.2±11.4)mm,较对照组的(38.4±9.7)%、(63.0±10.1)mm、(53.6±11.0)mm差异有统计学意义(P<0.05)。观察组治疗后心功能NYHA分级改善明显优于对照组(P<0.05)。均无明显不良反应发生。结论阶梯式卡维地洛治疗能明显逆转慢性心衰患者心室重塑,显著促进患者心功能改善。
Objective To analyze the effects of stepped carvedilol on ventricular remodeling and cardiac function in patients with chronic heart failure (chronic heart failure). Methods A total of 76 patients with chronic heart failure admitted to our hospital from March 2013 to March 2015 were randomly divided into two groups (38 in each). The control group was treated with conventional anti-heart failure. The observation group was given carvedilol Stepwise administration, compared the two groups before and after treatment, cardiac function, heart function classification and adverse reactions after treatment. Results After treatment, LVEF, LVEDD and LVESD were (48.8 ± 8.5)%, (56.2 ± 10.4) mm and (42.2 ± 11.4) mm, which was significantly higher than that of the control group (38.4 ± 9.7)%, (63.0 ± 10.1) mm and (53.6 ± 11.0) mm respectively (P <0.05). The improvement of NYHA classification in the observation group after treatment was significantly better than that in the control group (P <0.05). No obvious adverse reactions occurred. Conclusions Stepped carvedilol treatment can significantly reverse ventricular remodeling in patients with chronic heart failure and significantly improve cardiac function.