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目的探讨Survivin在胃癌中的表达及其与胃癌临床病理特征及预后的相关性。方法用免疫组织化学方法检测85例胃癌标本Survivin的表达,分析其表达与临床病理特征及预后之间的关系。结果Survivin在本组病例中表达的阳性率为37.65(32/85),Survivin的表达与肿瘤分化程度、淋巴结转移、肿瘤侵润深度及病理分期等病理特征无显著相关性(P>0.05);年龄≥60岁的患者Survivin表达的阳性率高于年龄小于60岁的患者,但差异无统计学意义(P>0.05);在Ⅰ、Ⅱ期病例中Survivin的表达与生存之间的关系无统计学意义(P>0.05),而Ⅲ期患者中Survivin阴性表达的患者2年累积生存率高于阳性表达的患者(P<0.05)。结论Survivin的表达与胃癌临床病理特征之间无相关性,在Ⅲ期胃癌患者中Survivin阳性表达是预后的不利因素。
Objective To investigate the expression of survivin in gastric cancer and its correlation with clinicopathological features and prognosis of gastric cancer. Methods Immunohistochemical method was used to detect the expression of Survivin in 85 specimens of gastric cancer. The relationship between the expression of Survivin and clinicopathological features and prognosis was analyzed. Results The positive expression rate of Survivin in this group was 37.65 (32/85). The expression of Survivin was not significantly correlated with pathological features such as tumor differentiation, lymph node metastasis, depth of tumor invasion and pathological stage (P>0.05). The positive rate of Survivin expression was higher in patients aged ≥60 years than in those less than 60 years old, but the difference was not statistically significant (P>0.05). There was no statistical relationship between the expression of Survivin and survival in stage I and II cases. The significance of the study was significant (P>0.05). However, the 2-year cumulative survival rate in patients with negative Survivin expression in stage III patients was higher than that in patients with positive expression (P<0.05). Conclusion There is no correlation between the expression of Survivin and the clinicopathological features of gastric cancer. The positive expression of Survivin in stage III gastric cancer is an unfavorable factor for prognosis.