论文部分内容阅读
目的:了解外用重组人粒细胞巨噬细胞集落刺激因子(rhGM-CSF)凝胶剂(金扶宁)及外用重组牛碱性成纤维细胞生长因子(rb-bFGF)(贝复济)治疗儿童Ⅱ度烧伤创面的有效性及安全性。方法:将2012年6月至2012年11月来我院就诊的小面积浅度烧伤患儿45例按抽签法随机分为三组,分别为金扶宁治疗组20例、贝复济治疗组20例、生理盐水对照组5例。金扶宁组予rhGM-CSF 0.5μg/cm2直接涂于创面,贝复济组给予rb-bFGF 0.03 mL/cm2直接均匀喷于创面,生理盐水组给予生理盐水0.03 mL/cm2直接均匀喷于创面,比较治疗组与对照组创面愈合时间。结果:创面愈合时间金扶宁组(8.619±0.944)d、贝复济组(10.766±1.369)d较对照组(13.850±0.398)d明显缩短,差异有统计学意义(P<0.05),用药期间患儿血常规及肝肾功相关指标的差异与药物应用无明显相关。结论:金扶宁及贝复济处理小面积浅Ⅱ度烧伤均较生理盐水能有效缩短愈合时间,加快愈合速度,对于儿童生长发育无明显影响,未发现明显不良反应,在儿童创面的治疗应用中安全、有效。
Objective: To investigate the effect of topical rhGM-CSF gelatinizer (JinFangNing) and topical recombinant bovine basic fibroblast growth factor (rb-bFGF) Effectiveness and safety of burn wounds. Methods: From April 2012 to November 2012, 45 children with small-area shallow burns treated in our hospital were randomly divided into three groups according to the method of lottery: 20 cases in Jinfu Ning group and 20 cases in Beifuji group , Saline control group of 5 cases. Jin Fu Ning group were given rhGM-CSF 0.5μg / cm2 directly applied to the wound, Bei Fuji group given rb-bFGF 0.03mL / cm2 directly spray evenly on the wound, the saline group given normal saline 0.03mL / cm2 directly spray evenly on the wound, compare The wound healing time in treatment group and control group. Results: The wound healing time in Jin Fu Ning group (8.619 ± 0.944) d and Bei Fuji group (10.766 ± 1.369) d was significantly shorter than that in control group (13.850 ± 0.398) d, the difference was statistically significant (P <0.05) Children’s blood and liver and kidney function related indicators of differences and drug application no significant correlation. Conclusion: Both Jinfuning and Baifuji treatment of superficial second-degree burns can shorten the healing time and speed up the healing compared with normal saline, and have no significant effect on children’s growth and development, no obvious adverse reactions, and safe application in children’s wounds ,effective.