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脓毒症(Sepsis)是严重创(烧)伤、休克、外科手术后常见的并发症,进一步发展可导致脓毒症休克、多器官功能障碍综合征(MODS)。尽管当今生物技术和医学监护手段飞速发展,但脓毒症的临床患病率和死亡率仍居高不下。据统计,重症监护室中60%死亡患者是由脓毒症所致;有关资料的分析表明,全球10%的死亡患者与脓毒症密切相关,每天约有1400人死于脓毒症。对于脓毒症的治疗,国际脓毒症联席会虽然推出了“2004严重脓毒症和脓毒症休克治疗指南”,但其实际上并没有创新的治疗方法,只是对现行的一些治疗方法的总结或重新评估,要真正实现2002年巴塞罗那宣言中“降低25%死亡率”的目标尚有距离。自上个世纪70年代,国内以王今达教授、王宝恩教授等为代表开展的中西医结合治疗本病的临床与基础研究,显示出中医药治疗本病具有潜在的优势。近年来北京地区以首都医科大学附属北京友谊医院、北京中医药大学东直门医院等单位牵头,对脓毒症的中西医结合诊治进行了深入研究;在北京市科委重大攻关项目“中西医结合降低感染性多脏器功能障碍病死率”及首都医学发展科研基金重大项目“北京地区脓毒症现状及脓毒症肾功能衰竭基础研究”将要结题之际,我们精选了一组论文,期望对广大从事危重病临床和科研工作的同仁有所启示。
Sepsis is a serious trauma, shock, and common complication after surgery. Further development may lead to septic shock and multiple organ dysfunction syndrome (MODS). Despite the rapid advances in biotechnology and medical surveillance today, the clinical prevalence and mortality of sepsis remain high. Statistics show that 60% of deaths from intensive care units are caused by sepsis. Analysis of relevant data shows that 10% of global deaths are closely related to sepsis and about 1,400 people die of sepsis every day. For the treatment of sepsis, the International Sepsis Joint Council introduced the “Guidelines for the Treatment of Severe Sepsis and Sepsis in 2004”, but there is actually no innovative treatment, but for some current treatment methods To sum up or reevaluate, there is a distance between achieving the goal of “lowering the 25% mortality rate” in the Barcelona Declaration of 2002. Since the 1970s, clinical and basic researches on the combination of TCM with Western medicine represented by Professor Wang Jinda and Professor Wang Bao’en have shown that TCM has potential advantages in treating this disease. In recent years, Beijing area led by Beijing Friendship Hospital Affiliated to Capital Medical University and Dongzhimen Hospital of Beijing University of Chinese Medicine and other units conducted an in-depth study on diagnosis and treatment of integrated traditional Chinese and Western medicine in sepsis. In the major project of Beijing Municipal Science and Technology Commission, “Integrative Medicine Reduced Infective multiple organ dysfunction mortality ”and the Capital Medical Research Fund project“ Beijing sepsis status and basic research on sepsis renal failure ”is about to conclude, we selected a group of papers, expectations The majority of critically ill clinical and research colleagues have some inspiration.