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目的观察环磷酰胺冲击疗法联合激素治疗肾病综合征(NS)的临床效果。方法选取2013年3月—2014年3月怀化市第二人民医院靖州分院收治的NS患者60例,按不同治疗方法分为观察组与对照组,各30例。观察组患者予以环磷酰胺冲击疗法联合激素治疗,对照组患者予以常规激素治疗。观察两组患者临床疗效、不良反应及各项指标变化情况。结果观察组患者总有效率为93.3%,高于对照组的80.0%,差异有统计学意义(P<0.05),观察组患者不良反应发生率低于对照组(P<0.05),两组患者治疗前尿蛋白定量、血浆总蛋白、血清清蛋白、血肌酐、内生肌酐清除率比较,差异无统计学意义(P>0.05),治疗后观察组患者尿蛋白定量低于对照组,血浆总蛋白、血清清蛋白高于对照组(P<0.05),治疗后两组患者血肌酐、内生肌酐清除率比较,差异无统计学意义(P>0.05)。结论环磷酰胺冲击疗法联合激素治疗NS的临床效果显著,可降低不良反应发生率,改善患者预后。
Objective To observe the clinical effect of cyclophosphamide shock therapy combined with hormone treatment of nephrotic syndrome (NS). Methods From March 2013 to March 2014, 60 NS patients admitted to Jingzhou Branch of Second People’s Hospital of Huaihua City were divided into observation group and control group according to different treatment methods, 30 cases in each group. Patients in the observation group were given cyclophosphamide combined with hormone therapy, and patients in the control group were given conventional hormone therapy. The clinical efficacy, adverse reactions and changes of various indexes in two groups were observed. Results The total effective rate in the observation group was 93.3%, which was higher than that in the control group (80.0%), the difference was statistically significant (P <0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P <0.05) Before treatment, urinary protein, plasma total protein, serum albumin, serum creatinine, endogenous creatinine clearance rate was no significant difference (P> 0.05), after treatment, the urinary protein in the observation group was lower than the control group, total plasma (P <0.05). There was no significant difference in serum creatinine and endogenous creatinine clearance between the two groups after treatment (P> 0.05). Conclusion Cyclophosphamide shock therapy combined with hormone treatment of NS has a significant clinical effect, which can reduce the incidence of adverse reactions and improve the prognosis of patients.