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目的探讨慢性阻塞性肺疾病(COPD)患者D二-聚体水平与深静脉血栓形成(DVT)及肺栓塞(PTE)的关系,提高COPD患者同时患有PTE和DVT的诊断意识。方法用酶联免疫吸附试验(ELISA)检测正常对照组(健康老年人)及COPD组患者血浆D-二聚体含量并比较其结果与DVT和PTE的关系。结果正常对照组D-二聚体值为(0.45±0.17)mg/L,>0.5 mg/L者占16%,而实验组>0.5 mg/L者占36.5%,其中并发症PTE、DVT的患者的D二-聚体值明显增高,甚至呈数十倍升高,而无其他疾病的COPD患者>0.5 mg/L者占总数的26.7%,其平均值为(0.50±0.15)mg/L。结论对所有COPD患者D二-聚体栓测有利于提高DVT和PTE的诊断率。
Objective To investigate the relationship between D-dimer level and deep venous thrombosis (DVT) and pulmonary embolism (PTE) in patients with chronic obstructive pulmonary disease (COPD) and to improve the diagnosis of COPD patients with both PTE and DVT. Methods Plasma D-dimer levels were measured by enzyme-linked immunosorbent assay (ELISA) in patients with normal controls (healthy elderly) and COPD patients and their relationship with DVT and PTE was compared. Results The D-dimer value was (0.45 ± 0.17) mg / L in the normal control group and 16% in the group of> 0.5 mg / L, while that in the experimental group> 0.5 mg / L was 36.5% Patients with D-dimer values were significantly higher, even at 10-fold increase, while COPD patients without other diseases> 0.5 mg / L accounted for 26.7% of the total, with an average of (0.50 ± 0.15) mg / L . Conclusions D-dimer test in all patients with COPD is helpful to improve the diagnostic rate of DVT and PTE.