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为了分析体液表皮生长因子（ＥＧＦ）含量与不明原因男性不育之间的相关性，本研究分别收集了３７例男性不育患者的血液、精液和唾液，根据精子计数将患者分成３组：Ａ组：＜２１×１０６／ｍｌ，Ｂ组：２１４０×１０６／ｍｌ，Ｃ组：＞４０×１０６／ｍｌ。根据精子活动率将患者分成４组：Ｉ组：０２０％，Ｉ组：２１％～４０％，ＩＩ组：４１％～６０％，ＩＶ组：６１％～８０％。用放射免疫法测定血浆、精浆和唾液ＥＧＦ浓度。结果：各组血浆ＥＧＦ含量与对照比较无显著差异，Ａ、Ｂ和Ｃ组的唾液ＥＧＦ浓度均显著高于对照（Ｐ＜０．０５），而且Ａ组精浆ＥＧＦ也显著高于对照（Ｐ＜０．０５）。Ｉ、ＩＩ和ＩＶ组的唾液ＥＧＦ浓度都显著高于对照（Ｐ＜０．０５）。对照组的唾液ＥＧＦ含量与精子数量呈显著负相关（ｒ＝－０．８７５，Ｐ＜０．０５）。唾液ＥＧＦ（主要来自颌下腺）与精子发生有相关性。唾液ＥＧＦ浓度异常与不明原因男性不育的关系值得重视。
In order to analyze the correlation between body fluid epidermal growth factor (EGF) and unexplained male infertility, blood, semen and saliva were collected from 37 male infertile patients in this study. Patients were divided into 3 groups based on sperm counts: A Group: <21 x 106 / ml, Group B: 2140 x 106 / ml, Group C:> 40 x 106 / ml. Patients were divided into 4 groups according to sperm motility: Group I: 020%; Group I: 21% -40%; Group II: 41% -60%; Group IV: 61% -80%. Plasma, seminal plasma and saliva EGF concentrations were measured by radioimmunoassay. Results: There was no significant difference in the content of EGF between plasma and control group. The salivary EGF concentration in group A, B and C were significantly higher than that in control group (P <0.05), and the level of EGF in group A was significantly higher than that in control group <0.05). The salivary EGF concentrations in groups I, II and IV were significantly higher than those in controls (P <0.05). The salivary EGF content in the control group was significantly negatively correlated with the sperm count (r = -0.875, P <0.05). Salivary EGF (mainly from the submandibular gland) is associated with spermatogenesis. The relationship between abnormal salivary EGF concentration and unexplained male infertility deserves attention.