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目的调查并分析第三代头孢菌类抗菌药物的药理及应用现状。方法统计并分析医院头孢菌类抗菌药物出库记录(14 546例)、用药频度(DDDs)及应用方法。结果第二代头孢菌类抗菌药物DDDs高于第一代、第三代及三代复方制剂,差异有统计学意义(P<0.05),头孢哌酮、头孢他啶、头孢曲松、头孢噻肟主要使用方法有口服、静脉滴注、静脉注射或肌内注射。结论第三代头孢菌类抗菌药物抗菌作用强,抗菌谱广,但需把握药物药理作用及使用方法,合理用药,以确保药物作用效果,保证患者用药安全。
Objective To investigate and analyze the pharmacology and application status of the third generation cephalosporin antibiotics. Methods Statistics and analysis of hospital cephalosporin antibacterial drugs out of the library records (14 546 cases), medication frequency (DDDs) and application methods. Results The second generation cephalosporins antibacterials DDDs higher than the first, third and third generation compound preparations, the difference was statistically significant (P <0.05), cefoperazone, ceftazidime, ceftriaxone, cefotaxime main use Methods are oral, intravenous drip, intravenous injection or intramuscular injection. Conclusion The third-generation cephalosporin antibacterial drugs have strong antibacterial effect and broad antimicrobial spectrum. However, it is necessary to grasp the pharmacological effects and methods of drug use and rational use of drugs to ensure the drug effect and ensure the safety of patients.