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目的：探讨急性胰腺炎患者血清白细胞介素6( IL-6)及肿瘤坏死因子α( TNF-α)的改变及与病情的关系。方法选择2010年2月至2012年2月兰州大学第二医院住院治疗的116例急性胰腺炎患者为研究对象,其中重症急性胰腺炎患者66例,轻型急性胰腺炎患者50例。采用酶联免疫吸附测定法检测患者血清IL-6及TNF-α水平,探讨两者与病情的关系。结果重症急性胰腺炎患者血清IL-6和TNF-α水平分别为(97.62±13.42)μg/L和(5.49±2.40)μg/L,显著高于轻型急性胰腺炎患者(42.17±8.72)μg/L和(2.46±1.37)μg/L(P<0.05)；两组患者治疗后1周血清IL-6和TNF-α水平均显著下降,分别为(22.76±4.38)μg/L和(2.41±1.24)μg/L及(13.23±3.95)μg/L和(1.69±0.82)μg/L(P<0.05)；重症急性胰腺炎存活患者的血清IL-6及TNF-α水平显著低于死亡患者(P<0.05)。结论血清IL-6及TNF-α水平与急性胰腺炎患者疾病严重程度密切相关,可作为临床评估病情、疗效及预后的指标。“,”Objective To explore the change of IL-6 and TNF-αin acute pancreatitis and their relationship with disease condition. Methods 116 patients with acute pancreatitis who treated in Second Hospital Affiliated to Lanzhou University from 2010 February to 2012 February were selected as research subjects, including 66 cases of severe acute pancreatitis and 50 cases of mild acute pancreatitis. Serum IL-6 and TNF-αlevel were detected by En-zyme linked immunosorbent assay, and their relationships with disease were studied. Results The serum IL-6 and TNF-α levels in patients with severe acute pancreatitis were (97. 62 ± 13. 42) μg/L and (5. 49 ± 2. 40) μg/L, sig-nificantly higher than those in patients with mild acute pancreatitis(42. 17 ± 8. 72) μg/L and (2. 46 ± 1. 37) μg/L (P<0. 05);After 1 weeks,the serum IL-6 and and TNF-levels were significantly decreased,respectively (22. 76 ± 4.38) μg/L and(2.41 ±1.24) μg/L,(13.23 ±3.95) μg/L and (1.69 ±0.82) μg/L(P<0.05)in two group patients;The serum IL-6 and TNF-αlevels in the survival of severe acute pancreatitis patients was significantly lower than the mortality in patients with(P<0. 05). Conclusions Serum IL-6 and TNF-α level closely related with the disease condition of acute pancreatitis, and they can be the indexes for evaluating disease, effect and prognosis.