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目的:评价选择动脉插管化疗(SIAC)在妇科中晚期恶性肿瘤治疗中的价值。方法:对128例中晚期妇科恶性肿瘤患者采用Seldinger法行超选择动脉插管化疗,主要药物有DDP、MMC、EPIA、ADM、5蛳Fu、DACT、CTX、MTX等。SIAC治疗患者2 ~ 4疗程后手术。结果:128例行SIAC的中晚期恶性肿瘤患者,116例获得再次手术机会,再次手术时术中见大部分肿瘤体积明显缩小,粘连程度明显好转,腹水不同程度消退。完全有效33例,部分有效75例,轻微有效13例,无效7例。经SIAC治疗,患者生存率较以往未行SIAC治疗的患者生存率明显提高,其2 a、5 a生存率分别为57.6 %、24.4 %。结论:超选择动脉插管化疗治疗妇科中晚期恶性肿瘤可使肿瘤缩小甚至消退,提高手术成功率,延长患者生存期。
Objective: To evaluate the value of SIAC in the treatment of advanced gynecologic malignancies. Methods: 128 patients with advanced gynecological malignant tumors were treated by superselective arterial cannulation with Seldinger’s method. The main drugs were DDP, MMC, EPIA, ADM, 5-Fu, DACT, CTX and MTX. SIAC treatment of patients after 2 ~ 4 courses of surgery. Results: Of 128 patients with advanced and advanced malignant tumors who underwent SIAC, 116 patients had the chance of reoperation. The volume of most of the tumors in operation was significantly reduced and the degree of adhesion was significantly improved. The degree of ascites subsided to varying degrees. 33 cases were completely effective, 75 partially effective, 13 slightly effective and 7 ineffective. Survival rate of patients treated with SIAC was significantly higher than that of patients without SIAC. The 2-year and 5-year survival rates were 57.6% and 24.4%, respectively. Conclusion: Superselective arterial intubation chemotherapy for advanced gynecologic malignancies can reduce or even eliminate the tumor, improve the success rate of surgery and prolong the survival of patients.