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青霉素族抗生素可引起过敏反应,使用前必须做皮内过敏试验。为保证青霉素皮试液的盾量,有人建议用枸橼酸钠等调节青霉素皮试液的pH以增加其热稳定性。但经临床使用反映有假阳性发生。本文作者采用双盲法,分别用枸橼酸钠缓冲液和生理盐水配制的青霉素皮试液进行了阳性率比较,并用相应的空白溶液进行了自身对照,经统计处理,结果表明:含有枸橼酸钠的青霉素皮试液具有很高的假阳性率(P<0.001),尤其是1岁以内的婴幼儿更易发生(P<0.001),应引起重视。
Penicillin antibiotics can cause allergic reactions, must be done before using intradermal allergy test. In order to ensure the amount of penicillin skin test solution, it was suggested that sodium citrate and other penicillin skin test solution to adjust the pH to increase its thermal stability. However, the clinical use of false positive occurred. The authors used double-blind method, respectively, with sodium citrate buffer and saline penicillin skin test solution was compared positive rate, and the corresponding blank solution for their own control, the statistical processing, the results show that: containing citron Sodium acid penicillin skin test solution has a very high false positive rate (P <0.001), especially in infants and young children within 1 year of age is more likely to occur (P <0.001), should pay attention.