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目的观察食管鳞状细胞癌(ESCC)组织中T细胞免疫球蛋白结构域分子3(TIM-3)表达,结合患者预后进行分析。方法收集豫北安阳肿瘤医院、南阳中心医院等河南食管癌高发区医院病理科存档的1994-2014年手术切除、石蜡包埋食管癌及癌旁组织蜡块225例,免疫组织化学方法(IHC)检测生存期<5年组、≥5年组共150例食管癌及75例癌旁组织中TIM-3子表达;Kaplan-Meier(K-M)法分析TIM-3表达与患者预后关系。结果生存期<5年组≥5年组、癌旁对照组间TIM-3表达差异有统计学意义,P<0.05;TIM-3蛋白表达与患者有无淋巴结转移有关,P<0.05;TIM-3表达与患者预后无关,P>0.05。结论阳性淋巴结转移者TIM-3表达增强;TIM-3不是患者预后危险因素。
Objective To observe the expression of T-cell immunoglobulin domain 3 (TIM-3) in esophageal squamous cell carcinoma (ESCC) tissues and to analyze the prognosis of patients with esophageal squamous cell carcinoma (ESCC). Methods A total of 225 surgical specimens of paraffin-embedded esophageal cancer and adjacent paraffin tissue from 1994 to 2014, including Anyang Cancer Hospital of Henan Province and Nanyang Central Hospital, were collected from Department of Pathology of Henan Esophageal Cancer Hospital. Immunohistochemistry (IHC) The TIM-3 expression was detected in 150 cases of esophageal cancer and 75 cases of paracancerous tissues with survival of less than 5 years and more than 5 years. Kaplan-Meier (KM) method was used to analyze the relationship between the expression of TIM-3 and the prognosis of patients. Results There was a significant difference in the expression of TIM-3 between the 5-year and 5-year survival groups (P <0.05); TIM-3 protein expression was correlated with lymph node metastasis (P <0.05) 3 expression has nothing to do with the prognosis of patients, P> 0.05. Conclusions TIM-3 expression is positive in patients with positive lymph node metastasis. TIM-3 is not a risk factor of prognosis.