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目的:探索黄体期促排卵方案在卵巢低反应患者中应用的可行性及其初步效果。方法:分析77例接受黄体期促排卵的不孕症患者的卵泡期和黄体期促排卵时血清激素水平及获卵数、胚胎情况和助孕结局。结果:经过卵泡期和黄体期2次取卵,77例均有取卵机会,且获得卵子的患者数和有胚胎冻存的患者数均比仅接受卵泡期取卵的患者数显著增加(P<0.001和P<0.05);卵泡期与黄体期扳机日内分泌水平亦有统计学差异(P<0.001),黄体期促排卵周期的回收卵子数、冷冻胚胎数均显著多于卵泡期(P<0.001);已接受了冻融胚胎移植(FET)的34例患者中20例获得了临床妊娠。结论:在卵巢低反应患者中实施黄体期促排卵取卵是可行的,可以增加获卵数及获得胚胎的机会,从而为提高妊娠率提供可能。
Objective: To explore the feasibility and preliminary effect of luteal phase ovulation induction in patients with low ovarian response. Methods: Serum hormone levels, number of oocytes retrieved, embryo status and pregnancy outcomes were analyzed during the follicular and luteal phase in 77 infertile women receiving luteal phase ovulation induction. RESULTS: After ovulation in follicular phase and luteal phase, 77 cases all had the chance of oviposition. The number of patients who obtained ovum and the number of patients with embryo cryopreservation were all significantly higher than that of those who received follicular phase only (P <0.001 and P <0.05). There was also a significant difference in the daily endocrine levels between the follicular phase and the luteal phase (P <0.001). The number of retrieved eggs and the number of frozen embryos in the luteal phase during ovulation induction were significantly more than those in the follicular phase (P < 0.001); 20 of 34 patients who had received a frozen-thawed embryo transfer (FET) achieved clinical pregnancy. Conclusion: It is feasible to promote ovulation in the luteal phase in patients with low ovarian response, which can increase the number of oocytes retrieved and the chance of obtaining the embryo, thus providing the possibility of increasing the pregnancy rate.