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Cardiorenal syndrome(CRS)is a clinical syndrome with a complex mechanism,and there is currently no specific treatment.Gingerol was confirmed to possess anti-inflammatory,antioxidant and cardioton-ic properties as cardiovascular pharmacological effects.However,in vivo studies have yet to prove that it can im-prove cardiac function and inhibit fibrosis in rats with cardiorenal syndrome.Methods In this study,34 male Sprague-Dawley(SD)rats were randomly divided into control(n=9),model(n=12)and gingerol groups(n=13).The model and the gingerol groups underwent ligation of the left anterior descending coronary artery and 5/6 sub-total nephrectomy to construct a type 2 cardiorenal syndrome rat model.The rats in gingerol group were injected intraperitoneally with 50 mg/kg gingerol.The same amount of saline was administered to both the control and the model groups.Following 4 weeks of treatment,the rat cardiac function and myocardial fibrosis were evaluated by cardiac ultrasound and blood biochemistry.Results Biochemical results showed that the brain natriuretic pep-tide(BNP)levels of gingerol group decreased(P＜0.05).Cardiac ultrasound revealed that gingerol improved car-diac systolic function and ventricular remodeling(P＜0.05).The systolic function of the model group was signifi-cantly decreased compared with the control group.Masson staining confirmed that the fibrosis area in the model group was significantly augmented than that in the control group,while the area of fibrosis in the gingerol group was diminished compared to the model group(P＜0.01).Moreover,immunofluorescence showed that compared with the control group,the expression of collagen 1,TGF-β1 and a-SMA was significantly increased in the mod-el group,and both collagen deposition and the expression of collagen I,TGF-β1 and α-SMA decreased in gin-gerol group.Immunohistochemistry revealed that the expression of collagen 1 and α-SMA was significantly in-creased in the model group compared with the control group,while it was decreased in gingerol group(P＜0.05).Conclusions Gingerol can improve the cardiac function and cardiac fibrosis in rats with cardiorenal syndrome.