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本文采用随机双盲、多中心、安慰剂对照试验评价了两种剂量的西拉普利(CIL)对高血压病人24小时血压的影响。来自3个中心的85例无并发症的轻、中度、原发性高血压病人参加了本研究。研究前停用一切能影响血压的药物。所有病人先进行4周单盲安慰剂期,然后随机分为三组:Ⅰ组:29例,口服CIL 2.5mg每日1次;Ⅱ组:29例,口服CIL 5mg每日1次;Ⅲ组:27例,口服安慰剂每日1次。每组给药时间均为8周。研究期间定时测定血压和心率。结果在给药8周时,Ⅰ、Ⅱ和Ⅲ组病人
This study evaluated the effects of two doses of Cilazapril (CIL) on 24-hour BP in hypertensive patients using a randomized, double-blind, multicenter, placebo-controlled trial. Eighty-five patients with mild, moderate, essential hypertension without complications were enrolled in this study. Disable all drugs that affect blood pressure before the study. All patients were treated with single blind placebo for 4 weeks and then randomly divided into three groups: group Ⅰ: 29 cases, oral CIL 2.5 mg once daily; group Ⅱ: 29 cases, oral CIL 5 mg daily; group Ⅲ : 27 cases, oral placebo once daily. Each group dosing time is 8 weeks. Blood pressure and heart rate were measured regularly during the study. Results At 8 weeks of administration, patients in groups I, II and III