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目的探讨老年男性中血清睾酮对代谢综合征各相关组分的影响。方法研究对象为48例老年男性,测定身高、体重、体质指数、腰围、血糖、血胰岛素、血脂以及血清睾酮浓度,并用稳态公式(HOMA)计算胰岛素抵抗(HOMA-IR),分析血清睾酮与代谢综合征(MS)各组分的关系。结果在老年男性中,随着MS组分数目增多,睾酮水平逐渐下降(P<0.05)。相关分析显示睾酮浓度和体质指数、腰围、空腹血糖、空腹胰岛素、HOMA-IR呈负相关,与胆固醇、甘油三酯、高密度脂蛋白及血压的相关性不明显。结论老年男性血清睾酮浓度与肥胖及胰岛素抵抗有密切关系,呈显著负相关。
Objective To investigate the effect of serum testosterone on related components of metabolic syndrome in elderly men. Methods Forty-eight elderly men were enrolled in this study. Height, weight, body mass index, waist circumference, blood glucose, blood insulin, serum lipid and serum testosterone were measured. HOMA was used to calculate insulin resistance (HOMA-IR) Metabolic syndrome (MS) components of the relationship. Results In elderly men, testosterone levels decreased gradually with increasing number of MS fractions (P <0.05). Correlation analysis showed that the testosterone concentration and body mass index, waist circumference, fasting blood glucose, fasting insulin, HOMA-IR was negatively correlated with cholesterol, triglyceride, HDL and blood pressure was not significantly related. Conclusion Serum testosterone concentration in elderly men is closely related to obesity and insulin resistance, showing a significant negative correlation.