对长期医源性促性腺激素衰退妇女单用促卵泡激素(FSH)对卵巢类固醇生成的作用进行探讨。 5例妇女每月肌注长效LA(Leuprolideacetate)并配合雌、孕激素反加治疗4～38个月,出现持续的垂体下调作用(down-regula-tion),停药1周后所有受试者每日皮下注射重组的FSH,第一周75IU/d,第二周150IU/d,第三周225IU/d。试验期间每2d进行阴道超声及血雌二醇(E_2)、孕激素(P)、雄烯二酮 To investigate the effect of FSH on ovarian steroidogenesis in women with long-term iatrogenic gonadotrophin decay. Five women took intramuscular injection of Leuprolide acetate once a month for 4 to 38 months with estrogen and progesterone antinociception. All patients underwent one week of down-regula tion, The daily subcutaneous injection of recombinant FSH, the first week of 75IU / d, the second week of 150IU / d, the third week of 225IU / d. Vaginal ultrasound and blood estradiol (E 2), progesterone (P), androstenedione