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1.本文概述了尿素降低眼压的原理、特点、临床应用的方法、效果及适应証等。 2.给13名青光眼患者按1.5克尿素/公斤体重口服尿素后,眼压于1小时即下降到正常范围內,1 1/2至4小时間較低,至8小时回到服药前高度。不論服药前眼压如何高,都能下降到較低的水平;眼压愈高,下降愈多。有些用pilocarpine及Diamox均未能降低眼压的患者,尿素均能奏效。 3.口服尿素后,房水流暢系数增加,流量减低,与尿素的降压作用有关。 4.服用尿素后,有一过性的头痛、噁心、口渴。于第2—3小时收縮压稍增加。 5.尿素保留灌腸,降压作用不大,缺点也較多,不适于作治疗用。
1. This article outlines the principle, characteristics, clinical application of methods, effects and indications of urea to reduce intraocular pressure. 2. To 13 glaucoma patients with 1.5 g of urea / kg body weight oral urea, intraocular pressure in 1 hour that fell to the normal range, 1 1/2 to 4 hours lower to 8 hours before returning to the height. No matter how high the pressure before taking medicine, can fall to a lower level; IOP higher, more down. In some patients who fail to reduce intraocular pressure with both pilocarpine and Diamox, urea works. 3. After oral administration of urea, aqueous humor coefficient increases, the flow rate decreases, and the role of antihypertensive effect of urea. After taking urea, there is a transient headache, nausea, thirst. Systolic blood pressure slightly increased in the first 2-3 hours. 5. Urea retention enema, antihypertensive effect is not large, disadvantages are more, not suitable for treatment.