目的　观察从复合季铵盐消毒剂中分离得到的洋葱假单胞菌对常用消毒剂的抗力。方法　以常用的氯和戊二醛消毒剂对其进行杀菌试验，并与对大肠杆菌和金黄色葡萄球菌相应的杀菌效果进行比较，以除菌后污染样液对大肠杆菌、金黄色葡萄球菌进行了杀菌试验和ＨＢｓＡｇ 抗原性破坏试验，对芽胞和白色念珠菌进行抑菌试验。结果　该洋葱假单胞菌对氯和戊二醛的抗力与大肠杆菌和金黄色葡萄球菌接近，污染样液除菌后１ ０００ 倍稀释对大肠杆菌和金黄色葡萄球菌仍有较好的杀菌效果，２０ 倍稀释可完全破坏ＨＢｓＡｇ 抗原性，和抑制枯草杆菌黑色变种芽胞的生长，１ ６００ 倍稀释可抑制白色念珠菌生长，而原液则不能抑制分离菌株的生长。结论　洋葱假单胞菌可在高浓度（１ ．６％ ）季铵盐消毒剂中大量生长，其对该类消毒剂抗力明显高于大肠杆菌、金黄色葡萄球菌、白色念珠菌、枯草杆菌黑色变种芽胞和ＨＢｓＡｇ，其对氯和戊二醛的抗力与大肠杆菌和金黄色葡萄球菌接近 Objective To observe the resistance of Pseudomonas cepacia isolated from compound quaternary ammonium disinfectants to common disinfectants. Methods The commonly used chlorine and glutaraldehyde disinfectant sterilization test, and with the corresponding bactericidal effect of Escherichia coli and Staphylococcus aureus were compared in order to remove bacteria contaminated sample of Escherichia coli, Staphylococcus aureus The bactericidal test and HBsAg antigenic destruction test, Bacillus and Candida albicans antibacterial test. Results The resistance of Pseudomonas cepacia to chloro and glutaraldehyde was close to those of Escherichia coli and Staphylococcus aureus. The dilution of the contaminated sample solution with 1000-fold dilution still had good bactericidal effect on Escherichia coli and Staphylococcus aureus , 20-fold dilution can completely destroy the antigenicity of HBsAg, and inhibit the growth of B. subtilis black mutant spores, 1 600-fold dilution can inhibit the growth of Candida albicans, while the original solution can not inhibit the growth of isolated strains. Conclusion Pseudomonas cepacia can grow in high concentration (1.6%) of quaternary ammonium salt disinfectant, its resistance to this kind of disinfectant is obviously higher than that of Escherichia coli, Staphylococcus aureus, Candida albicans, Bacillus subtilis black Variant sprouts and HBsAg, its resistance to chlorine and glutaraldehyde and Escherichia coli and Staphylococcus aureus close