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骨髓增生异常综合征(Myelodysplastic Syndrome,简称MDS)属造血干细胞的疾病,临床以贫血为主,可伴有白细胞及血小板减少与质的异常。它是由骨髓造血系统生成、分化和成熟功能紊乱引起的一组血液学异常综合征,并非一种独立性疾病。病人中约有1/4～1/5转化为急性白血病,多数病人将因急性白血病、骨髓衰竭、感染及出血致死。FAB协作组于1982年将其分为5型,即:(1)难治性的贫血(RA);(2)环状铁粒幼细胞难治性贫血(RAS);(3)原始细胞过多性难治性贫血(RAEB);(4)慢性粒单细胞白血病(CMML);(5)转化中的原始细胞过多性难治性贫血(RAEB—T)。现结合我们收治的28例MDS患者资料谈谈FAB分型问题。
Myelodysplastic syndrome (Myelodysplastic Syndrome, MDS for short) is a hematopoietic stem cell disease, anemia-based clinical may be associated with leukopenia and thrombocytopenia and quality abnormalities. It is a group of hematological abnormalities caused by disorders of bone marrow hematopoietic system that produce, differentiate, and mature, and are not an independent disease. About 1/4 ~ 1/5 of patients are converted to acute leukemia, and most patients will die of acute leukemia, bone marrow failure, infection and bleeding. The FAB collaborative group divided it into 5 types in 1982, namely: (1) refractory anemia (RA); (2) RAS; (3) (RAEB), (4) chronic myelomonocytic leukemia (CMML), and (5) RAEB-T in transformation. Now combined with our data of 28 cases of MDS patients to talk about FAB typing problems.