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Remarkable progress has been achieved for prophylactic and therapeutic interventions against human immunodeficiency virus type Ⅰ (HIV-1) through antiretroviral therapy.However,vaccine development has remained challenging.Recent discoveries in broadly neutralizing monocionai antibodies (bNAbs) has led to the development of multiple novel vaccine approaches for inducing bNAbs-like antibody response.Structural and dynamic studies revealed several vulnerable sites and states of the HIV-1 envelop glycoprotein (Env) during infection.Our review aims to highlight these discoveries and rejuvenate our endeavor in HIV-1 vaccine design and development.