本文试图回答长期服用氯丙嗪所致晶体和角膜色素沉着是否可逆?长期服用氯丙嗪对视力的危害程度如何?资料和方法:30个女性精神分裂症病人,年龄32-74岁,已服用氯丙嗪3～10年,日量100～825mg.随机分为两级,一组继续服氯丙嗪13人,一组换服甲硫达嗪12人,在三年半的观察期间内,病人服用氯丙嗪或甲硫达嗪的日量为300～400mg. This article attempts to answer long-term use of chlorpromazine caused by crystalloid and corneal pigmentation is reversible? Chronic long-term use of chlorpromazine on the degree of visual acuity? Materials and Methods: 30 female schizophrenia patients, aged 32-74 years, has taken Chlorpromazine 3 to 10 years, the daily dose of 100 ~ 825mg. Randomly divided into two groups, one group continued to take chlorpromazine 13, a group of methotrexate 12, in the three and a half years of observation period, Patients taking chlorpromazine or methldezine daily dose of 300 ~ 400mg.