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目的评估灵芝孢子对原发性肝癌术后肝功能的影响。方法 80例原发性肝癌切除术后患者随机分为对照组(常规护肝治疗)和治疗组(对照组基础上加灵芝孢子治疗),各40例。术后1d、3d、7d动态监测肝功能指标(ALT、AST、TBIL、ALB、PT)变化,比较灵芝孢子治疗对原发性肝癌术后肝功能的影响。结果术后第1天,治疗组和对照组均出现较明显的肝功能损害。经1周治疗后,治疗组较对照组肝功能明显改善(P=0.032),无一例出现肝功能不全,而对照组2例出现肝功能不全。两组术后并发症和药物不良反应无明显差异(P分别为0.453、0.874)。结论灵芝孢子可以较好地改善原发性肝癌患者术后肝功能的损害,改善患者的预后。
Objective To evaluate the effect of Ganoderma lucidum spores on postoperative liver function of primary liver cancer. Methods Eighty patients with primary hepatocellular carcinoma after resection were randomly divided into control group (conventional hepatoprotective therapy) and treatment group (control group plus Ganoderma lucidum spore therapy), 40 cases in each group. The changes of liver function indexes (ALT, AST, TBIL, ALB, PT) were dynamically monitored on the 1st, 3rd, 7th day after operation, and the effect of Ganoderma lucidum spores on postoperative liver function was compared. Results On the first day after operation, the liver damage was obvious in the treatment group and the control group. After one week of treatment, the liver function of the treatment group was significantly improved compared with the control group (P = 0.032), no case of liver dysfunction, while the control group 2 cases of liver dysfunction. There were no significant differences in postoperative complications and adverse drug reactions between the two groups (P = 0.453, 0.874, respectively). Conclusion Ganoderma lucidum spores can improve the damage of liver function and improve the prognosis of patients with primary liver cancer.