氨中毒是肝性脑病发生的重要因素,约75%的肝昏迷患者有血氨升高,特别是在碱中毒情况下氨以NH_3形式,大量透过血脑屏障,干扰大脑糖代谢,ATP产生减少,同时乙酰胆碱生成减少,使抑制性神经介质GABA形成增多等而出现肝昏迷。实践证 Ammonia poisoning is an important factor in the development of hepatic encephalopathy. About 75% of patients with hepatic coma have elevated serum ammonia, especially in the case of alkalosis, NH3 in the form of ammonia, a large number of blood-brain barrier, interfere with cerebral glucose metabolism, ATP production Reduce, at the same time reduce the generation of acetylcholine, the formation of inhibitory neurotransmitter GABA increase and so appear hepatic coma. Practice certificate