本研究评价了健康成人志愿者接受酵母重组乙型肝炎（HB）疫苗初免和加强免疫后7年抗-HBs的持久性。1986年10月,188名血清阴性的健康成人志愿者（男性117名,女性71名,平均年龄为23.3岁）按0-1-2月程序接种3剂20μg酵母重组HB疫苗。并于第12个月加强1剂。159名志愿者完成了全程免疫。于初免后8年对63人（40％）采血,其中54名接种者 This study evaluated the persistence of anti-HBs in healthy adult volunteers seven years after receiving the yeast recombinant hepatitis B (HB) vaccine and boosting. In October 1986, 188 serum-negative healthy adult volunteers (117 males and 71 females with a mean age of 23.3 years) received three doses of 20 μg yeast recombinant HB vaccine on a 0-1-2 month schedule. And strengthen one dose in the 12th month. 159 volunteers completed the whole immunization. Eight (63) (40%) blood samples were collected eight years after the initial immunization, of which 54 were vaccinated