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吸收期相互作用:食物(“正规”早餐)或雷尼替丁(Ranitidine),皆不影响环丙沙星(ciprofloxacin)吸收。同时口服含镁或铝的抗酸药,可使环丙沙星(500 mg)血浆峰值下降6～10倍;但同时口服含钙的抗酸药,血清环丙沙星浓度则无变化。镁、铝离子使环丙沙星吸收减少,抗菌活性减弱;可能由于环丙沙星与镁或铝形成螯合物所致。哌仑西平和N-丁基溴化东莨菪碱延迟胃排空,可使环丙沙星吸收迟缓;相反,metclopramide加速胃排空,则使环丙沙星吸收
Absorption Interactions: Food (“regular” breakfast) or ranitidine did not affect ciprofloxacin uptake. At the same time oral administration of anti-acid drugs containing magnesium or aluminum, ciprofloxacin (500 mg) plasma peak decreased 6 to 10 times; but at the same time oral calcium-containing antacids, serum ciprofloxacin concentrations did not change. Magnesium and aluminum ions reduced the absorption of ciprofloxacin and decreased the antibacterial activity. It may be due to the formation of chelates between ciprofloxacin and magnesium or aluminum. Pirenzepine and N-butyl-scopolamine delayed gastric emptying, allowing delayed absorption of ciprofloxacin; on the contrary, metclopramide accelerated gastric emptying, the ciprofloxacin absorption