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近年来国外从临床和实验室对免疫与再障的关系作了深入的研究和探讨。在临床上应用免疫抑制剂如环磷酰胺、6-甲基强地松龙、环孢素A等治疗再障获得疗效,说明免疫在再障的发病机理中起着一定的作用。应用体外造血细胞培养技术和近代免疫检查方法进一步从实验室提供了免疫介导再障的证据,包括淋巴细胞、血清中抑制因子及干扰素和单核细胞等的作用。目前免疫介导再障的发病机理尚未完全闸明,不同病例的发病机理可能各不相同。
In recent years, foreign countries from the clinical and laboratory on the relationship between immune and aplastic made in-depth study and discussion. In the clinical application of immunosuppressive agents such as cyclophosphamide, 6-methylprednisolone, cyclosporin A treatment of aplastic anemia efficacy, indicating that immunization in the pathogenesis of aplastic anemia play a role. The use of in vitro hematopoietic cell culture techniques and modern immunoassay methods further provide evidence of immune-mediated aplastic anemia in the laboratory, including lymphocytes, inhibitors of serum and interferon and monocytes. At present, the pathogenesis of immune-mediated aplastic anemia has not yet completely locked out, the pathogenesis of different cases may vary.