论文部分内容阅读
维生素D_3经过肝脏后转化为25-羟基维生素D_3,它是血中的主要循环形式,再经过肾脏的特殊酶系作用生成生物活性很强的1,25-二羟基维生素D_3(1,25(OH)_2D_3),它除了以激素的形式调节钙离子在细胞内外转运外,对各种血细胞也有影响。本文主要阐述1,25(OH)_2D_3对正常造血组织,正常血细胞和白血病细胞的影响。一、对正常造血组织的影响 1.对集落形成单位增殖的影响用正常人骨髓细胞培养发现,1,25(OH)_2D_3可以促进粒系或单核-巨噬细胞集落形成单位(CFU-C)在粘附细胞层和非粘附细胞层中的增殖;对单核细胞集落形成单位(CFU-M)和粒-巨噬细胞集落形成单位(CFU-GM)的增殖也有促进作用;对粒细胞集落形成单
Vitamin D 3 is converted to 25-hydroxyvitamin D 3 through the liver, which is the main circulating form in the blood. It is also produced by the special enzyme system of the kidney to produce 1,25-dihydroxyvitamin D 3 (1,25-OH ) _2D_3), which in addition to hormones in the regulation of intracellular calcium transport, the various blood cells also have an impact. This article focuses on 1,25 (OH) _2D_3 on normal hematopoietic tissue, normal blood cells and leukemia cells. First, the impact on normal hematopoietic tissue 1 on the proliferation of colony forming units with normal human bone marrow cells found that 1,25 (OH) _2D_3 can promote granulocyte or monocyte - macrophage colony forming units (CFU-C ) Proliferation in the adherent and non-adherent cell layers; it also promoted the proliferation of monocyte colony forming units (CFU-M) and granulocyte-macrophage colony forming units (CFU-GM) Cell colony forming a single