近10年来,抗生素耐药性问题日趋严重。头孢菌素类抗生素因具广谱抗菌活性和低毒性而常被用于治疗细菌感染,而且能安全地用于那些对青霉素过敏而依赖于此类抗生素的病人,但由于其耐药菌株的不断增加,这类药物用于一线常规治疗已明显减少,甚至许多医疗机构已弃用,而改用其他抗生 In the past 10 years, the problem of antibiotic resistance has become increasingly serious. Cephalosporin antibiotics are often used for the treatment of bacterial infections because of their broad-spectrum antibacterial activity and low toxicity, and can safely be used in patients who are allergic to penicillins and rely on such antibiotics. However, due to the continuous growth of resistant strains Increase, the first-line treatment of such drugs has been significantly reduced, and even many medical institutions have been abandoned, and switch to other antibiotics