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Objective:To evaluate bepato protective and antioxidant capacity of Melochia corchorifolia (M.corchorifolia)aerial part extracts.Methods:Antioxidant activitywas evaluated by using three free radicals(Superoxide,Hydroxyl and DPPH) and hepatoprotective activity was assessed against CCl_4 induced liver intoxication in ruts.Results:The extracts produced concentration dependent percentage protection in decrease of serum enzymes and percentage inhibition on free radicals.Among all extracts methanol extract showed better activity with percentage protection of SGOT(78.98%),SGPT(79.65%),ALP(82.48%) and total bilirubin(80.0%)levels against CCl_4 liver intoxication and also methanolic extract showed better activity with IC_(50) values on superoxide. hydroxyl and DPPH radicals were 127μg.240μg and 179μg.Conclusions:From the results obtained during the study it could be concluded that M.corchorifolia aerial part extracts have antioxidant and hepaloprotective components.Further study is necessary for isolation and characterization of bioactive molecules which are responsible for hepatoprotective and antioxidant activity.
Objective: To evaluate bepato protective and antioxidant capacity of Melochia corchorifolia (M.corchorifolia) aerial part extracts. Methods: Antioxidant activitywas evaluated by using three free radicals (Superoxide, Hydroxyl and DPPH) and hepatoprotective activity was assessed against CCl_4 induced liver intoxication in ruts Results: The extract produced concentration dependent percentage protection in decrease of serum enzymes and percentage inhibition on free radicals. Among all extracts methanol extract showed better activity with percentage protection of SGOT (78.98%), SGPT (79.65%), ALP (82.48% ) and total bilirubin (80.0%) levels against CCl_4 liver intoxication and also methanolic extract showed better activity with IC_ (50) values on superoxide. hydroxyl and DPPH radicals were 127 μg. 240 μg and 179 μg. Conclusions: From the results obtained during the study it could be concluded that M.corchorifolia aerial part extracts have antioxidant and hepaloprotective components. Future study is necessary for isolation and characterization of bioactive molecules which are responsible for hepatoprotective and antioxidant activity.